Therapeutically Applicable Research to Generate Effective Treatments (TARGET)

Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is the collaborative effort of a large, diverse consortium of extramural and NCI investigators. The goal of the effort is to accelerate molecular discoveries that drive the initiation and progression of hard-to-treat childhood cancers and facilitate rapid translation of those findings into the clinic. TARGET projects provide comprehensive molecular characterization to determine the genetic changes that drive the initiation and progression of childhood cancers.The dataset contains open Clinical Supplement, Biospecimen Supplement, RNA-Seq Gene Expression Quantification, miRNA-Seq Isoform Expression Quantification, miRNA-Seq miRNA Expression Quantification data from Genomic Data Commons (GDC), and open data from GDC Legacy Archive.

治疗应用型研究以生成有效治疗方案（TARGET）是一项由众多外部及NCI调查员组成的庞大、多元化的联盟共同努力的成果。该努力的目的是加速推动难以治疗的儿童癌症起始和进展的分子发现，并促进这些发现迅速转化为临床应用。TARGET项目提供了全面的分子表征，以确定驱动儿童癌症起始和进展的遗传变化。该数据集包含来自基因组数据共享（GDC）的开放性临床补充、生物样本补充、RNA-Seq基因表达量化、miRNA-Seq异构体表达量化、miRNA-Seq miRNA表达量化数据，以及来自GDC遗产存档的开放数据。