Age-associated DNA methylation changes in Xenopus frogs

Here we present clear patterns of age-associated changes in DNA methylation in the aquatic vetebrate species Xenopus tropicalis. We generated nine whole-genome bisulfite sequencing (WGBS) datasets from three distinct age groups (young, approx. 1 year old; mature, approx. 5 years old; old, approx. 9 years old) to characterize the gene- and chromosome-scale changes. Overall design: We have generated whole genome bisulfite sequencing (WGBS) profiles in nine Xenopus tropicalis samples representing young, mature and old adults to study how DNA methylation relates to aging in frogs.