Hemorrhage from cerebral cavernous malformations: the role of associated developmental venous anomalies

Objective

To determine the role of associated developmental venous malformations (DVA) in intracranial hemorrhage (ICH) caused by cerebral cavernous malformations (CCM).

 

Methods

We analyzed patient registry data of 1219 patients with cavernous malformations treated in our institution between 2003 and 2018. Patients with spinal and familial CCM as well as patients without complete MRI data were excluded. Impact of various variables on ICH as mode of presentation was assessed using multivariate binary logistic regression analysis. Kaplan Meier/Cox regression analysis was performed to analyze cumulative 5-year-risk for (re-) hemorrhage and identify baseline predictors of this outcome.

 

Results

Seven-hundred-thirty-one CCM patients were included. Multivariate logistic regression confirmed statistically significant negative correlation with DVA (Odds ratio (OR) 0.635 (0.459 – 0.878)) and positive correlation with brainstem localization (OR 6.277 (95% CI 4.287 – 9.191)...