Additional file 2 of Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial

Additional file 2: Table S1. Further baseline characteristics of participants according to intervention group. Table S2. Further baseline characteristics of participants according to weight loss quartiles. Table S3. Diversity indices across timepoints according to intervention groups. Table S4. Changes in bacteria (order) abundance across time points according to intervention group. Table S5. Changes in bacteria (class) abundance across time points according to intervention group. Table S6. Changes in anthropometric measurements, body composition, clinical markers and blood-based biomarkers by weight loss quartiles after 24 and 50 weeks. Table S7. Diversity indices across timepoints according to weight loss quartiles. Table S8. Intervention effects on plasma bile acids concentrations (nmol/L) after 12 weeks according to weight loss quartiles. Table S9. Changes in the concentrations of acylcarnitines and amino acids according to weight loss quartiles after 12, 24 and 50 weeks. Table S10. Intervention effects on plasma TMAO, betaine and choline concentrations (μmol/L) across timepoints according to weight lossquartiles. Table S11. Comparison of bacteria (phylum) relative abundances across timepoints according to intervention groups. Table S12. Comparison of bacteria (class) relative abundances across timepoints according to intervention groups. Table S13. Comparison of bacteria (order) relative abundances across timepoints according to intervention groups. Table S14. Comparison of bacteria (family) relative abundances across timepoints according to intervention groups. Table S15. Comparison of bacteria (genus) relative abundances across timepoints according to intervention groups. Table S16. Comparison of within-group bacteria (phylum) relative abundances at each timepoint relative to baseline. Table S17. Comparison of within-group bacteria (class) relative abundances at each timepoint relative to baseline. Table S18. Comparison of within-group bacteria (order) relative abundances at each timepoint relative to baseline. Table S19. Comparison of within-group bacteria (family) relative abundances at each timepoint relative to baseline. Table S20. Comparison of within-group bacteria (genus) relative abundances at each timepoint relative to baseline. Table S21. Study, sample, experiment and run accession numbers of all 16S data generated in the HELENA Trial.