Induction of mouse totipotent stem cells by a defined chemical cocktail [scRNA-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185001
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We demonstrate induction and long-term maintenance of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs) by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. These cells, which we designated as ciTotiSCs (chemically induced totipotent stem cells), resembled mouse totipotent 2C-embryo stage cells at both transcriptome and epigenome level. ciTotiSC single-cell RNA-seq and single-cell RNA-seq of tdTomato+ cells from placenta and yolk sac of E13.5 chimera
创建时间：
2022-08-08
