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RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

ChEBI2014-02-13 更新2026-07-21 收录

白血病分子机制

癌症基因功能验证

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-36592 数据链接链接失效反馈

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资源简介：

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

应用场景：

创建时间：

2014-02-13

白血病分子机制

基因表达谱分析

Background: MLL (KMT2A)-EB1 (MAPRE1) fusion was identified in a patient with de novo pro-B acute lymphoblastic leukemia. To investigate the leukemogenesis of MLL-EB1 fusion, a retroviral transduction

NIAID Data Ecosystem100

EGAS00001000058-sc-20130718a - samples

白血病分子机制

基因组学测序

The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblastic leukemia (ALL), is acquired in utero but requires additional somatic mutations for overt leukemia. We used exome and low-cover

NIAID Data Ecosystem40

ZFP36L2 post-transcriptionally controls acute myeloid leukemia differentiation (MOLM13 HiC). ZFP36L2 post-transcriptionally controls acute myeloid leukemia differentiation (MOLM13 HiC)

白血病分子机制

三维基因组学

Genome-wide assessment of TADs in AML cells Overall design: TAD domains in MOLM13 AML cells

NIAID Data Ecosystem40

Transcriptomic effects of forced expression of FOXO3, PRDM1⍺ and PRDM1β in pre-B ALL cell line 697 [exp1]. Transcriptomic effects of forced expression of FOXO3, PRDM1⍺ and PRDM1β in pre-B ALL cell line 697 [exp1]

白血病分子机制

肿瘤抑制基因

Lentiviral constructs expressing candidate tumoure suppressor genes were transduced into 697 cells. Of the candidates FOXO3, two isoforms of PRDM1 (⍺ and β) suppressed growth in-vitro and in-vivo. To

NIAID Data Ecosystem80

DUX4-r neomorphic activity depending on GTF2I in acute lymphoblastic leukemia [RNA-seq]

白血病分子机制

转录组靶点鉴定

Translocations producing rearranged versions of the transcription factor DUX4 (DUX4-r) are one of the most frequent causes of B-cell acute lymphoblastic leukemia (B-ALL). DUX4-r retains the DNA bindin

NIAID Data Ecosystem40

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

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