Supplementary Data 1-2.xlsx

To study the metabolic reprogramming of circulating miR-204 mediated lipolysis in adipose tissue (figshare), we performed lipid metabolomics analysis and detected an enrichment of phosphatidylethanolamine in serum from 4T1 tumour-bearing mice than 4T1/miR-204 KO mice and sEVs educated adipocytes in vitro (Extended Data Figs.5e-h). PE (18:2-19:1) significantly stimulated the proliferation, migration and invasion of 4T1 and MDA-MB-231 cancer cells in a dose-dependent manner (Extended Data Figs.5i and 5j), suggesting the pro-tumour effect of PE mediated by miR-204/VHL mediated leptin signaling pathway.