Table_10_Dietary copper intake and risk of myocardial infarction in US adults: A propensity score-matched analysis.DOC

ObjectivesMost studies have examined the association between serum copper and myocardial infarction, but there is little evidence of the association between dietary copper intake and myocardial infarction.Materials and methodsThe study included a total of 14,876 participants from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression model was used to analyze the association between dietary copper intake and the risk of myocardial infarction. To reduce selection bias, we use nearest neighbor propensity score matching (PSM) in a 1:2 ratio. Restricted cubic spline (RCS) method is used to study the non-linear relationship. Subgroup stratification was used to further investigate the association between copper intake and myocardial infarction.ResultsThe median dietary copper intake was 1.0825 mg/day. A myocardial infarction had occurred in approximately 4.4% (655) of the participants. Before and after matching, multivariate logistic regression models revealed a negative correlation between dietary copper intake and the risk of myocardial infarction. The higher quartile of subjects had a noticeably lower risk of myocardial infarction in comparison to those in the first quartile of copper intake. According to RCS findings, dietary copper intake and myocardial infarction have a non-linear and dose-response relationship. According to stratified analysis, the dietary copper intake was a substantial protective element for those who were ≥ 50 years old, female, 25 ≤BMI

研究目标：众多研究已探讨血清铜与心肌梗死之间的关联，然而，关于膳食铜摄入与心肌梗死之间关联的证据却相当有限。研究方法：本研究纳入了2011至2018年国家健康与营养检查调查（NHANES）中的14,876名参与者。采用多变量逻辑回归模型分析了膳食铜摄入与心肌梗死风险之间的关联。为减少选择偏差，我们以1:2的比例采用了最近邻倾向得分匹配（PSM）。通过限制性三次样条（RCS）方法研究非线性关系。采用亚组分层进一步探究铜摄入与心肌梗死之间的关联。研究结果：膳食铜摄入中位数为1.0825毫克/天。大约4.4%（655人）的参与者发生了心肌梗死。在匹配前后，多变量逻辑回归模型揭示了膳食铜摄入与心肌梗死风险之间的负相关关系。与铜摄入第一四分位数相比，高四分位数个体的心肌梗死风险明显较低。根据RCS研究结果，膳食铜摄入与心肌梗死之间存在非线性剂量-反应关系。根据分层分析，膳食铜摄入是≥50岁、女性、BMI 25≤的女性的一项重要保护因素。