PRP was pretreated with various doses of rivaroxaban for 15 min, and then stimulated by 1.0 μg/ml collagen or vehicle for 5min. The reaction was terminated by the addition of ice-cold EDTA (10 mM) sol

NIAID Data Ecosystem40

Exome sequencing identifies a novel frameshift mutation of a-actin in a Chinese family with macrothrombocytopenia and mild bleeding

血小板研究

突变体鉴定

By employing whole exome sequencing, we identified a novel frameshift mutation (NM_001130004: c.398_399insTGCG, p.F134AfsX60) of ACTN1 in a Chinese family with IMTP and mild epistaxis and/or gingival

NIAID Data Ecosystem30

Supplementary Material for: Flagellins of Salmonella Typhi and Nonpathogenic Escherichia coli Are Differentially Recognized through the NLRC4 Pathway in Macrophages

先天免疫识别

炎症小体激活

Flagellin is recognized by both Toll-like receptor (TLR)5 and NAIP5/NLRC4 inflammasome receptors. We hypothesized that the flagellins derived from different bacteria might differentially activate TLR5

NIAID Data Ecosystem40

Human platelets and megakaryocytes express defensin alpha 1

血小板研究

抗菌防御机制

Platelets are anucleate cells that have a role in several innate immune functions, including the secretion of proteins with antimicrobial activity. Several studies have demonstrated the ability of pla

NIAID Data Ecosystem30

Platelets fuel the inflammasome activation of innate immune cells

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