MicroRNA expression data from human brain tissue with focal cortical dyplasia, type II

Focal cortical dysplasia (FCD) is a type of malformation of cortical development and its main clinical manifestation is medically intractable epilepsy We aimed to investigate whether abnormal gene regulation, mediated by microRNA, could be involved in FCD type II, in view of to help clarify the molecular mechanism leading to this type of cortical malformation. Microarray profiling of microRNA was performed on human brain tissue. We used formalin-fixed paraffin-embedded (FFPE) tissue and GeneChip® 1.0 miRNA array (Affymetrix, Santa Clara, USA). We included nine samples from patients with FCD type II (type IIa, n = 4; type IIb, n = 5) and five controls.