Genomic and Clinical Findings in Myeloid Neoplasms with PDGFRB Rearrangement [seq]

Here we characterized a series of 14 cases with myeloid neoplasms using cytogenetic, single nucleotide polymorphism array, and next generation sequencing. Overall design: Sequencing analysis of thirty genes, recurrently mutated in myeloid malignancies and included in the Myeloid Solution SOPHiA GENETICS (Saint-Sulpice, Switzerland), was performed on cases with 5q32/PDGFRB involvement. 13 cases were investigated at diagnosis and in 8 cases material from remission was also analyzed.