BC_cardiotox: A cardiotoxicity dataset for breast cancer patients

The BC_cardiotox database is a result of the collaboration between the University of A Coruña and the University Hospital of A Coruña. It contains information about 531 breast cancer patients and aims to enable the scientific community in conducting new research on cancer therapy-related cardiac dysfunction (CTRCD). The development of this side effect has important clinical and prognostic implications, and the availability of good predictors may allow its early detection. Although some risk factors are known, they are not sufficient to predict which patients will develop CTRCD during treatment. Therefore, in clinical practice it is recommended to monitor the appearance of CTRCD through blood laboratory tests and cardiac imaging tests. The echocardiogram, which allows to assess various parameters of the structure and function of the heart, is the main diagnostic tool. The Tissue Doppler Imaging (TDI), which shows the velocity of contraction and relaxation of the cardiac muscle, can be obtained by using this technique. This information, measured before treatment, may help in the early identification of CTRCD. Since the TDI shows a velocity as a function of time, it can be preprocessed to obtain a functional datum.<br>For each patient, baseline clinical variables are available, as well as the preprocessed baseline TDI. The code for the preprocessing of image data is also provided, together with two TDI images for reproducibility issues. The code is implemented in the statistical software R.<br>Corresponding author: Beatriz Piñeiro-Lamas ([e-mail] / [e-mail])

BC_cardiotox数据库是拉科鲁尼亚大学（University of A Coruña）与拉科鲁尼亚大学医院合作构建的数据集。该数据集收录了531名乳腺癌患者的相关临床信息，旨在为科学界开展癌症治疗相关心脏功能障碍（cancer therapy-related cardiac dysfunction, CTRCD）的相关研究提供支撑。
癌症治疗相关心脏功能障碍的发生具有重要的临床与预后学意义，优质的预测因子有助于实现该并发症的早期筛查。目前虽已明确部分CTRCD危险因素，但仍不足以精准预测患者在治疗过程中是否会发生该并发症。因此，临床实践中推荐通过血液实验室检测与心脏影像学检查，监测CTRCD的发生与进展。其中，超声心动图可评估心脏结构与功能的多项参数，是当前CTRCD诊断的主要工具。组织多普勒成像（Tissue Doppler Imaging, TDI）能够显示心肌收缩与舒张的速度，可通过超声心动图技术获取此类数据。此类在抗肿瘤治疗前测得的TDI数据，可辅助早期识别CTRCD。由于TDI输出的是随时间变化的心肌速度曲线，可通过预处理提取其功能特征参数。
对于每位患者，本数据集均提供了基线临床变量与预处理后的基线TDI数据。同时，为保障研究可重复性，我们还提供了图像数据的预处理代码，以及两份TDI影像示例。该预处理代码基于统计软件R实现。
通讯作者：Beatriz Piñeiro-Lamas（电子邮箱：[e-mail] / [e-mail]）

搜集汇总

背景与挑战

背景概述

BC_cardiotox是一个包含531名乳腺癌患者临床和功能变量的数据集，专注于癌症治疗相关心脏功能障碍（CTRCD）的研究。数据集提供了基线临床变量、预处理后的TDI数据及相关的R预处理代码，旨在帮助早期识别CTRCD。