Epigenetic Transgenerational Alterations to Stress Response in Brain Gene Networks and Behaviour

We used microarrays to determine genes expressed differentially in rats' 4 brain areas - basolateral amygdala (BLA), primary and secondary motor cortex (Crtx), CA1 of the hippocampus (CA1), and CA3 of the hippocampus (CA3) - due to Vinclozolin treatments of their grand-grandmothers and/or to stress in adolescence age.我们采用微阵列（microarrays）技术，对大鼠的四个脑区——基底外侧杏仁核（basolateral amygdala, BLA）、初级运动皮层与次级运动皮层（primary and secondary motor cortex, Crtx）、海马CA1区（CA1 of the hippocampus, CA1）以及海马CA3区（CA3 of the hippocampus, CA3）——的差异表达基因进行鉴定，探究受试大鼠曾祖母的乙烯菌核利（Vinclozolin）处理、受试大鼠青春期应激，或二者共同作用所诱导的基因表达差异。