ENGINEERING OF IMMUNOGLOBULIN DOMAINS
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a V H， the Cys may be introduced at any one of positions 47-49 and any one of positions 67-71， based on Kabat numbering; in one example， the Cys may be introduced at positions 49 and 69， based on Kabat numbering. In the case where the sdAb scaffold is a VL， the Cys residues may be introduced at any one of positions 46-49 and any one of positions 62-66， based on Kabat numbering; in one example， the Cys residues may be introduced at positions 48 and 64， based on Kabat numbering.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
