Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

SURF4 is a cargo receptor that has been implicated in the intracellular trafficking of PCSK9 and APOB - proteins involved in cholesterol transport and metabolism. We generated hepatic SURF4-deficient mice (Surf4(fl/fl) Alb-Cre+) to investigate the physiologic role of SURF4 in vivoSURF4是一种货物受体（cargo receptor），已被证实参与PCSK9与APOB的细胞内转运过程，这两类蛋白均参与胆固醇的转运与代谢调控。我们构建了肝脏特异性SURF4条件性敲除小鼠（Surf4(fl/fl) Alb-Cre+），以在体探究SURF4的生理功能。