16S sequencing of mouse gut microbiome during SARS-CoV2 infection. mouse gut metagenome

4 independent experiments were performed in which K18-hACE2 mice were infected intranasally with SARS-CoV2, isolate USA-WA1/2020 19 (BEI resources #NR52281). Feces were collected longitudinally and 16S sequencing was performed on extracted bacterial DNA. Samples are labeled as followed for each experiments: Experiment LB1: CTRL (mock infected), LD (10 PFU of SARS-CoV-2), HD (10000 PFU of SARS-CoV-2) Experiment LB5: 0 (mock infected), 100 (100 PFU of SARS-CoV-2), 1000 (1000 PFU of SARS-CoV-2) Experiment LB6: 0 (mock infected), 10000 (10000 PFU of SARS-CoV-2) Experiment LB7: 0 (mock infected), 10000 (10000 PFU of SARS-CoV-2)