MOESM2 of Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Additional file 2. Aggregation propensity scores and inter-isoform score comparison for all human protein isoforms. Predicted aggregation propensity for all “high-confidence” human protein isoforms (derived from ActiveDriverDB) was calculated using the modified PAPA algorithm (see Methods section for details). Scores and corresponding full protein sequences are indicated for all isoforms, along with the maximum PAPA score among all isoforms mapping to the same gene, the difference between the PAPA score for the indicated isoform and the maximum PAPA score among related isoforms, and the protein sequence corresponding to the highest-scoring related isoform. Additionally, the PLAAC algorithm was used to analyze the same sequences. A binary variable indicates if the protein contains a PLAAC-predicted PrLD that overlaps with the PAPA-predicted PrLD for high-scoring proteins only and, if so, the position of the PLAAC-predicted PrLD