Fecal microbiota transplantation alleviates depression-like behavior induced by CUMS and CUMS+DSS in mice by activating the BDNF / PI3K / Akt pathway via the microbiota gut-brain axis

the aim of this study was to elucidate the therapeutic mechanisms of FMT on depression and the mechanisms through which ulcerative colitis promotes depression in a depression model of C57BL/6 mice induced by chronic unpredictable mild stress (CUMS) and CUMS combined with dextran sulfate sodium (DSS).