Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse
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https://www.ncbi.nlm.nih.gov/sra/SRP261665
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资源简介：
YAP and TAZ are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has revealed their critical importance for embryonic development of the heart, vasculature and gastrointestinal mesenchyme. The aim of this study was to determine the functional role of YAP/TAZ in adult smooth muscle cell in vivo. Overall design: Distal colon and urinary bladder from 3 controls (Myh11CreERT2-negative-Yap1/Wwtr1 floxed) and 3 knockout (Myh11CreERT2-positive-Yap1/Wwtr1 floxed) were isolated and snap frozen in liquid nitrogen 7 days after the first (out of 5) tamoxifen injections
创建时间：
2020-11-06
