Microbiota Brain Axis in Alzheimers Disease MIND Diet Induced Effects

Alzheimers disease is a public health concern and the current study leverages a phase III randomized, interventional clinical trial to evaluate the ability of a dietary intervention to influence age associated cognitive decline in a population at risk for Alzheimers disease. Diet influences the intestinal microbiota, thus the current study investigated diet induced changes in the intestinal microbiota as a mechanism by which dietary interventions exert beneficial effects on cognition and Alzheimers disease pathogenesis. Subjects fecal baseline samples were analyzed using 16S rRNA gene amplicon sequencing. The relationship between the microbiota and baseline clinical and experimental variables were evaluated.