Biologic Treatment Outcomes in Refractory Bullous Pemphigoid: An Evidence Base Review

Bullous pemphigoid (BP) is an autoimmune disorder characterized by tense blisters, urticarial plaques and intense pruritis. Initial treatment typically involves the use of topical and oral steroids; however, non-steroidal agents and biologics can also be used in refractory cases. This systematic review examines the treatment outcomes in BP refractory to conventional therapies, treated with biologics.

大疱性天疱疮（BP）是一种以紧张性水疱、荨麻疹样斑块和剧烈瘙痒为特征的自身免疫性疾病。初始治疗通常涉及局部和口服类固醇的使用；然而，在难治性病例中，也可使用非甾体药物和生物制剂。本系统综述旨在探讨对常规治疗难治的大疱性天疱疮采用生物制剂治疗的治疗效果。