S1 Data -

Fig 2 tab: Inverse time to threshold values (h-1) for individual quadruplicate wells seeded with 10−2 or 10−3 dilutions of IM samples with the IM sample ID numbers shown in the “Patient” column. Fig 3 tab: Inverse time to threshold values (h-1) for individual quadruplicate wells seeded with 10−3 dilutions of IM samples with the IM sample ID numbers shown in the “Patient” column. For samples 6 and 7, data from an additional 4 wells are shown. Fig 4 tab: log SD50/mg tissue values calculated for individual IM biopsies from end-point dilution data. Fig 5A tab: Inverse time to fluorescence threshold comparisons between first (biopsy 1) or second (biopsy 2) duodenum segments from a given patient for the IM sample ID numbers shown in the “Patient” column. Data are from quadruplicate wells seeded with 10−3 IM dilutions. Fig 5B tab: Log SD50/mg tissue values calculated for two IM biopsies from the same patient from end-point dilution analysis. Fig 6 tab: Individual IM log SD50/mg tissue values, UPDRSIII scores, constipation scores, and disease durations (y) associated with the designated IM sample ID in the “Patient” column. Fig 7 tab: Top 2 rows: Inverse time to threshold values (h-1) for individual quadruplicate wells seeded with 10−3 or 10−4 dilutions of IM samples with the IM sample ID numbers shown in the “Patient” row. sAD group: Analogous data from reactions seeded with 10−5 or 10−8 dilutions of sAD brain homogenate. The sAD spiked 10−5 group: data from reaction wells seeded with 1:1 mixtures 10−5 sAD BH and the designated tissue dilution of HC IM30. S2A and S2B Figs tabs: Quadruplicate ThT fluorescence readings as function of reaction time (h) for reactions seeded with 10−3 dilutions of IM sample IDs given the top row.
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