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Dissecting the contributions of cooperating cancer gene mutations to phenotype and drug susceptibility with patient-derived iPSCs

NIAID Data Ecosystem2026-05-25 收录

癌症基因功能建模

干细胞药物筛选

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP108379 数据链接链接失效反馈

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资源简介：

Isogenic iPSC models of SRSF2-mutant MDS

应用场景：

创建时间：

2018-03-27

心房颤动模型

干细胞药物筛选

Our study aims to illustrate the potential use of atrial iPSC-CMs for modeling AF in a dish, elucidating the underlying cellular mechanisms, and identifying novel mechanism-based therapies custom-tail

NIAID Data Ecosystem110

Swift Induction of Human Spinal Lower Motor Neurons and Robust ALS Cell Screening via Single-Cell Imaging

运动神经元疾病模型

干细胞药物筛选

This study presents a newly developed method to rapidly and efficiently induce human spinal lower motor neurons (LMNs) from induced pluripotent stem cells (iPSCs) for elucidation of pathomechanism or

NIAID Data Ecosystem50

Correlation for drug response values between BPH and NCI60 panels.

药物敏感性预测

干细胞药物筛选

The correlation was calculated for the cell lines that are in both panels.

Figshare2015-12-02 更新20

Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs. Homo sapiens

神经肌肉疾病模型

干细胞药物筛选

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations of the survival of motor neuron 1 (SMN1) gene. In the pathogenesis of SMA, pathological changes of the neuromuscular junct

NIAID Data Ecosystem70

Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s Disease II

克罗恩病纤维化模型

干细胞药物筛选

Background: We previously reported Crohn’s Disease (CD) ileal macrophage and fibroblast gene expression modules linked to future strictures, and identified small molecules which may reverse this gene

NIAID Data Ecosystem30

Dissecting the contributions of cooperating cancer gene mutations to phenotype and drug susceptibility with patient-derived iPSCs

资源简介：

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