Functional genomics to enhance aflatoxin resistance in poultry

Complete elimination of AFB1 in turkey feed is not possible, innovative methods are needed to protect turkeys against the numerous diseases exacerbated by this feed contaminant. Developing mechanism-based genetic markers to increase resistance of poultry to AFB1 represents an achievable, cost-effective, and efficient strategy to reduce the morbidity and mortality associated with numerous diseases of significant economic impact to the poultry industry. Our analysis of the transcriptome response to AFB1 challenge between domestic and wild turkeys in liver, spleen and intestinal tissues will identify numerous targets for gene regulation and better characterize the physiological response of turkeys exposed to AFB1.

在饲料中完全消除黄曲霉毒素B1（AFB1）是不可能的，因此需要创新的方法来保护火鸡免受由这种饲料污染物加剧的众多疾病的侵害。开发基于机制的遗传标记，以增强家禽对AFB1的抵抗力，代表了一种可行、经济高效的战略，旨在降低与众多疾病相关的发病率和死亡率，这些疾病对家禽业具有显著的经济影响。我们对家火鸡和野生火鸡在肝脏、脾脏和肠道组织中受到AFB1挑战后转录组反应的分析，将识别出众多基因调控的目标，并更好地描述火鸡暴露于AFB1时的生理反应。