The gene regulation landscape of MITF in lung adenocarcinoma

MITF is a transcription factor and identified as a oncoprotein in melanoma, but its role in lung adenoacrcinoma is still unknown. This study sought to investigate the effects of MITF on the biological behavior and global gene expression profiles in lung adenocacinoma cells. We used expression microarrays to identify the global gene alterations in lung adenocacinoma cell line, CL1-0 cells after ectopic expressing three shRNA for knockdown MITF expression. Ectopic expressing three shMITF and scrembles in high-expressed MITF lung cancer cell line, CL1-0.