Genome-wide significant associations (p−10) involving unknown metabolites.

We observe associations at 15 genetic loci that involve genes from various biological processes. Note that most of these genes code for proteins that are related to metabolic activities in the body, thereby providing information that allows to derive concrete hypotheses on the biochemical identity of each unknown. Previously published associations with known metabolites and other phenotypic traits (derived from the GWAS catalog [26]) provide further evidence on specific parts of a pathway in which the unknown might be involved. Chromosomal locations are reported with respect to the positive strand of human genome build 36.1.