Research data for article: Structural modifications of lipid membranes exposed to statins – Langmuir monolayer and PM-IRRAS study

The effects of selected statins on the structure and properties of lipid membranes composed of zwitterionic (1,2-dimyristoyl-sn-glycero-3-phosphocholine, DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, DMPE) or anionic (1,2-dimyristoyl-sn-glycero-3-phospho-L-serine, DMPS) lipids were studied by Langmuir technique combined with polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) and Brewster angle microscopy (BAM). The interactions of three statins: pravastatin, fluvastatin, and cerivastatin with the polar region of the lipids forming the membrane were monitored by PM-IRRAS and the changes of the overall monolayer structure and organization were described based on surface pressure vs. area per molecule measurements and Brewster angle microscopy.