Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons.
收藏PubMed Central1994-06-21 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC44137/
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资源简介：
Mutations in DNA underlie carcinogenesis, inherited pathology, and aging and are generally thought to be introduced during meiosis and mitosis. Here we report that in post-mitotic neurons specific frameshift mutations occur at high frequency. These mutations were identified in vasopressin transcripts in magnocellular neurons of the homozygous Brattleboro rat and predominantly consist of a GA deletion in GAGAG motifs. Immunocytochemistry provides evidence for similar events in wild-type rats. However, the diseased state of the Brattleboro rat, resulting in a permanent activation of vasopressin neurons, enhanced the mutational rate. These data reveal hitherto unrecognized somatic mutations in nondividing neurons. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-06-21
