On the partial volume effect in magnetic particle imaging

This dataset contains raw and processed data used to evaluate the partial volume effect (PVE) in magnetic particle imaging (MPI), an emerging tomographic imaging modality that visualizes superparamagnetic iron oxide nanoparticle (SPION) distributions with high sensitivity and quantitative accuracy. The dataset includes raw MPI images in NRRD and DICOM formats, optical images of scanned phantoms in TIFF format, and processed Excel files with quantitative analyses. Data were obtained using Feraheme and VivoTrax+ tracers scanned with various phantom geometries (prisms, cylinders, and capillaries) and characteristic sizes. Additional experiments included scans of VivoTrax+ phantoms across multiple concentrations and at two independent sites. MPI image processing was performed using a reported Wiener filter, with outputs such as signal recovery coefficients, signal-to-noise ratios, and voxel-based reconstructions.

The dataset is organized by model geometry and includes both raw data and processed results, enabling analysis of signal distribution, peak and plateau signal values, and image resolution effects. Researchers can use these data to study the PVE in MPI, evaluate the impact of finite resolution on signal quantification, and develop methods to sharpen MPI images or correct for PVEs. The files are compatible with standard data visualization and analysis tools such as 3DSlicer, Horos, and MATLAB, while Excel files are ready for direct interpretation.

This dataset has broader relevance for advancing quantitative imaging techniques in MPI and beyond by providing insights into the influence of object size and shape on imaging accuracy. The dataset is provided for non-commercial scientific purposes.

Methods
Data were collected using magnetic particle imaging (MPI) scanners to evaluate the partial volume effect (PVE) in imaging superparamagnetic iron oxide nanoparticle (SPION) distributions. Two tracers, Feraheme and VivoTrax+, were imaged in 3D-printed phantoms of varying geometries and sizes, including prisms, cylinders, and capillaries. MPI scans were conducted under controlled conditions at two independent sites (University of Florida and Magnetic Insight, Inc.). Additional experiments included imaging phantoms with varying tracer concentrations. A Wiener filter was applied to process select images of VivoTrax+ phantoms to enhance resolution. Quantitative analyses were performed to estimate signal recovery coefficients, signal-to-noise ratios, image size, and voxel-based signal distributions.