Triflic Acid-Catalyzed Highly Stereoselective Friedel−Crafts Aminoalkylation of Indoles and Pyrroles
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https://figshare.com/articles/dataset/Triflic_Acid_Catalyzed_Highly_Stereoselective_Friedel_Crafts_Aminoalkylation_of_Indoles_and_Pyrroles/2953615
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资源简介：
A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched α-trifluoromethyl-α-(heteroaryl)-glycine derivatives
via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3-trifluoro-pyruvate-α-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group
provided the products in high yields and excellent enantioselectivities.
创建时间：
2016-06-03
