Transcriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention

Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecule inhibitors would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of alpha lipoic acid (ALA), a naturally existing antioxidant, in targeting senescent cells via induction of programmed cell death. This study demonstrates the impact of alpha-lipoic acid as a medicinal compound on the expression profile of senescent cells and provides a strong rationale for its future use in geriatric medicine. Overall design: Examination of in vitro efficacy of alpha-lipoic acid, a non-sedating antioxidant with evidence of efficacy in the medication of symptomatic diabetic neuropathy that has not been evaluated in the setting of fibromyalgia treatment, in treating human senescent cells. This assay was performed beyond previous studies reporting alpha-lipoic acid's antioxidant and anti-inflammatory effects as a traditional herbal medicine, as well as its efficacy in improvement of inflammatory diseases and diabetes.