Interleukin-1 (IL-1) structural pathway

Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads). doi:10.1371/journal.pcbi.1003470.g002

该数据集收录于http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470，通过整合相关通路及文献信息，重建了IL-1信号传导通路。此详尽的IL-1信号传导图谱展示了蛋白质之间的相互作用及其引发的细胞事件。着色节点代表具有实验确定的三维结构的蛋白质，而白色节点则为无三维结构的蛋白质。边代表蛋白质之间的相互作用（直线/虚线箭头与蛋白质可用的/不可用的三维结构相关）或导致细胞事件（如细胞周期或基因表达）的关联（以圆形头部开始的虚线箭头）。doi:10.1371/journal.pcbi.1003470.g002