FCGR2A and FCGR2B SNPs are associated with atopy.

FCGR2A SNP (FcγRIIA-131His>Arg, rs1801274) is significantly associated with atopy in family-based association tests (FBAT). Logistic regression analysis also demonstrated that FCGR2A SNP is significantly associated with atopy and that the FcγRIIA-131His (allele frequency: 0.488) is a protective allele against atopy (P = 0.027, OR 0.732, 95%CI: 0.555–0.965). The FCGR2A SNP is also associated with asthma (P = 0.011) and BHR (P = 0.012) in FBAT.The FCGR2B SNP (FcγRIIB-187Ile>Thr, rs1050501) is significantly associated with atopy (P = 0.003, OR 1.758, 95%CI: 1.209–2.556) in logistic regression analyses adjusted for age and sex. The FCGR2B SNP is not associated with asthma and BHR (P>0.05).