Affinity selection-mass spectrometry data of discovered ligands against single biomolecular targets (MDM2, ACE2, 12ca5) from the Pentelute Lab of MIT

This dataset contains affinity selection-mass spectrometry data of discovered ligands against single biomolecular targets. Several of these AS-MS discovered ligands were taken forward for experimental validation to determine the binding affinity (KD) as measured by biolayer interferometry (BLI) to the listed target protein. If listed as a "putative binder," AS-MS alone was used to isolate the ligands to the target, with KD < 1 uM required and often observed in orthogonal assays, though there is some (< 50%) chance that the ligand is nonspecific.