WP4879 - Overlap between signal transduction pathways contributing to LMNA laminopathies - Homo sapiens

Laminopathies resulting form a range of LMNA mutations result in a range of tissue specific phenotypes. These rare diseases may be attributed to a symptomatic overlap characterized by the convergence of lamin A downstream signaling pathways. Lamin A is expressed in differentiating cells and thus this pathway highlights the major molecular signaling pathways misregulated during hMSC differentiation due to varying LMNA mutations.