Bilateral recordings of EEGs, LFPs, and tremor in people with essential tremor under DBS-OFF and DBS-ON conditions

TaskContinuous DBS: Each participant was asked to maintain a tremor‐provoking posture such as raising both arms to shoulder level with flexed elbows and the fingers of both hands pointing to the centre while sitting. The task was repeated in 6–8 blocks. Each block involved holding the tremor‐provoking posture for approximately 30 s, followed by 30 s rest. The task was repeated in both DBS-OFF and DBS-ON conditions. Data were collected from in total 15 participants (raw data were shared for 12 participants, while data for the remaining three were not shared due to ethical considerations). 1) Raw dataRaw data for each participant are stored in directories ‘0001’ to ‘0015’. In each folder, you will find two ‘.mat’ files for the raw data in DBS-OFF and DBS-ON conditions. The same data in the format of ‘.smr’ that can be visualised in Spike2 are also provided. Data structureEach raw data file contains six variables, including ‘FileName’, sampling rate (‘SR’), channel names (‘WvTits’), data matrix (‘WvData’), markers (‘markerData’, values 2 and 3 indicate the start and end of each posture holding block), and marker timestamps (‘markerTime’, timestamps for the corresponding marker values in ‘markerData’).2) Processed dataThere are three processed ‘.mat’ files, including: ‘myTable_2023_09_01.mat’ contains trial-by-trial results, that can be used to generate the figures and tables in the published paper (He et al., 2025, Brain). Note the subID in the processed data table doesn’t match the numbering of the raw data directories.3) Source MATLAB CodeThe main code file is ‘Cortico_thalamic_tremor_circuit_DBS.m’. Others are functioning files, code to convert ‘SMR’ format to ‘mat’ format, spike2 library files, and pre-processed results. With the provided raw and/or processed data, results in all figures and tables of the paper should be able to be reproduced.