DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice. DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice

Knock out of Dnmt3a in AgRP neurons leads to a sedentary, adiposity-prone adult phenotype associated with widespread changes in DNA methylation and gene expression. Overall design: Genome-wide bisulfite-seq and RNA-Seq of FACS-sorted neural (NeuN+) nuclei from the arcuate nucleus of the hypothalamus.