Approach to Tertiary-Type β‑Hydroxyl Carboxamides Through Sc(OTf)<sub>3</sub>‑Catalyzed Addition of Ynamides and Ketones
收藏NIAID Data Ecosystem2026-03-11 收录
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An efficient approach to access functionalized tertiary-type β-hydroxyl carboxamides has been developed through Sc(OTf)3-catalyzed addition of ynamides and substituted ketones. Water was found to be an important reaction substrate, and the solvent was not needed in this process. A broad range of substituted ynamides and ketones was well applicable to the reaction with excellent chemical selectivities. Moreover, several chiral β-hydroxyl carboxamides 3j–3r were prepared with excellent regioselectivities and outstanding diastereoselectivities.
创建时间：
2019-11-28
