Crystal Structure of Human Beta Secretase in Complex with compound 11d
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Crystal Structure of Human Beta Secretase in Complex with compound 11d Descriptor: (1R,3S,4S,5R)-3-(4-amino-3-fluoro-5-{[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxy}benzyl)-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1-oxide, Beta-secretase 1, GLYCEROL Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2013-07-30 Release date: 2013-08-28 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2013-07-30
