LD reference panels constructed using the All of Us (CDRv7, Controlled Tier) data

All of Us Reference Panels LD reference panels construction Select genetic variants that are available in the All of Us (CDRv7, Controlled Tier) array genotype dataset. The following variant filtering criteria were applied: (a) located on sex chromosomes; (b) missing value frequency > 0.03; and (c) MAF < 0.01. LD blocks were defined according to the LD block definition in PRS-CSx [Ref] (the start and end base pair position of the blocks of the LD reference panels used in PRS-CSx). LD blocks were saved in matrices with the "dgCMatrix" class and in "rds" file format. Sample size African American: 62,331 Hispanic: 59,640 Number of variants African American: 993,783 Hispanic: 875,221