RNA-seq of human choroid plexus epithelial cells infected and uninfected with Neisseria meningitidis in presence or absence of the Erk1/2 inhibitor U0126

The Gram-negative pathogen Neisseria meningitidis has been demonstrated to use the choroid plexus as an entry gate into the central nervous system, where it can induce meningitis. The global transcriptome of immortal human choroid plexus epithelial cells, which were infected in vitro with N. meningitidis, was analysed via RNA-seq. Infections were carried out with the serogroup B wild type strain MC58 and capsule-deficient mutant in presence or absence of the Erk1/2 inhibitor U0126.