Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice
收藏NIAID Data Ecosystem2026-03-14 收录
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资源简介：
Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4. Overall design: RNA-seq from Cardiac myocytes from 4 control (WT) and 4 Myh6-cre:LmnaF/F vehicle treated and 4 Myh6-cre:LmnaF/F JQ1 treated
创建时间：
2023-03-20
