The summary statistics of GWAS for individual deviations of total GMV

To investigate genetic variants contributing to individualized brain
aging, GWAS using estimated total GMV at 60 years old as the phenotype
were conducted. This phenotype was derived by adding individual specific
deviations to the population averaged total GMV, thus providing additional
information compared to studies using only cross-sectional neuroimaging
phenotypes. The dataset identified six independent single nucleotide
polymorphisms (SNPs) at genome-wide significance level (P < 5 ×
10-8), most of which could be further validated by previous studies using
population averaged brain aging phenotypes.   The file
“UKB_TGMV60y_sumstats_DuanEtAl2023.gz” contains results from the
genome-wide association studies (GWAS) for individual deviations of total
gray matter volume (GMV) relative to the population average at 60 years.
 Detailed information about generation of the data, QC and GWAS
can be found in the related manuscript.