Construction of 3,6-Difluoropyridones via a Double Defluorinative [3 + 3] Annulation of α‑Fluoro-α-sulfonylacetamides with 2‑CF3‑Alkenes

A remarkably simple and efficient double defluorinative [3 + 3] annulation approach involving N-phenyl-α-fluoro-α-phenylsulfonylacetamide and 2-CF3-alkenes to access N-phenyl-3,6-difluoropyridone derivatives has been achieved. The key to the success of this single-step synthesis of difluoropyridones is the strategic utilization of 2-CF3-alkenes for consecutive allylic and vinylic substitution reactions and a desulfonylation cascade. We could also show that these difluoropyridones serve as a versatile platform for C-6-selective defluorinative functionalizations.