Gene expression in clavicular cortical hyperostosis. Gene expression in clavicular cortical hyperostosis

Clavicular cortical hyperostosis (CCH) is a sterile inflammatory bone disorder of unknown etiology, clinically characterized by pain and/or swelling of the clavicle. The aim of the study was to identify and confirm specific gene expression patterns in patients with CCH. Overall design: Total RNA was isolated from whole blood of 18 children with diagnosis of CCH, as well as 8 age and sex matched control participants without diagnosis of chronic inflammatory disease. Of those, 5 patients and 4 controls were utilized in the microarray experiments, while the rest were used in the qPCR analysis.