Global population analysis of HLA class I affinity toward proteasome-generated peptides from five main SARS-CoV-2 spike protein RBD variants

Global data on relative abundance of SARS-CoV-2 S protein RBD peptides in samples, generated by human constitutive (c20S) and immune (i20S) proteasomes, calculated HLA class I EL ranks, percentage of HLA class I alleles coverage, average HLA class I haplotype protective index and percentage of individuals from 28,104 with at least 1 positive HLA class I allele in haplotype. List of 305 HLA class I alleles, covering 98% haplotypes of 28,104 individuals deposited in Allele Frequency Net Database. Referencing of proteasome-generated N-terminally extended peptides to core HLA class I CD8+ T cell epitopes listed in the Immune Epitope Database (IEDB). Convoluted relative abundance of SARS-CoV-2 S protein RBD peptides in samples, generated by c20S and i20S proteasomes. Spearman correlation between HLA class I haplotypes positive for two major SARS-CoV-2 S protein RBD epitopes in different populations and COVID-19-related deaths/cases ratio. Analysis of population frequency of SARS-CoV-2 S protein RBD epitopes-binding HLA class I molecules in different countries. Total amount of COVID-19-related deaths/cases in different countries before and after 12/01/2021. Interactive plot representing relative abundance of SARS-CoV-2 S protein RBD peptides in samples, generated by c20S and i20S proteasomes with indication of positive HLA class I alleles and respective EL ranks. Interactive plot with searchable interface representing sequence distribution of SARS-CoV-2 S protein RBD peptides, generated by proteasomes, with indication of positive HLA class I alleles and respective EL ranks.