Discovery of 7-THP chromans: BACE1 inhibitors that reduce A-beta in the CNS
收藏Protein Data Bank Japan2024-11-27 更新2026-03-21 收录
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Discovery of 7-THP chromans: BACE1 inhibitors that reduce A-beta in the CNS Descriptor: (4R,4a'S,10a'S)-2-amino-8'-(2-fluoropyridin-3-yl)-1-methyl-3',4',4a',10a'-tetrahydro-1'H-spiro[imidazole-4,10'-pyrano[4,3-b]chromen]-5(1H)-one, Beta-secretase 1, NICKEL (II) ION Authors: Vigers, G.P.A, Smith, D. Deposit date: 2013-09-30 Release date: 2014-05-14 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of 7-tetrahydropyran-2-yl chromans: beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid beta-protein (A beta ) in the central nervous system. J.Med.Chem., 57, 2014
创建时间：
2013-09-30
