Changes in mRNA transcripts in retina of miR-29a knockout mice

The mature mammalian retina results from a complex series of developmental events. A lot of work now exists on the organization, function, and development of mouse retina, and the high-throughput technologies for gene expression analyses have helped us to obtain deep insight into the mechanism about the genes that control the retinal neurogenesis and vasculogenesis. mRNA profiles of retinas from miR-29a KO mice and wild type mice of eight-week-old were generated by deep sequencing.成熟哺乳动物视网膜的形成源自一系列复杂的发育事件。目前已有大量针对小鼠视网膜的组织结构、功能及发育过程的研究工作，而基因表达分析的高通量技术（high-throughput technologies）助力我们深入解析调控视网膜神经发生（retinal neurogenesis）与血管发生（vasculogenesis）的基因机制。本研究通过深度测序（deep sequencing）获取了8周龄miR-29a基因敲除（miR-29a KO）小鼠与野生型（wild type）小鼠的视网膜mRNA表达谱。