Crystal structure of a Mn(II)-based complex and application of its nanoparticles for treatment activity on peri-implantitis by reducing inflammatory responses

A novel coordination polymer (CP), namely, [Mn(tib)2(NO3)2]n (1, tib = 1,3,5-tri(1H-imidazol-1-yl)benzene) has been prepared under hydrothermal condition and characterized by elemental analyses, infrared spectroscopy and single-crystal X-ray diffraction analyses. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the complex 1 to generate nanoscale 1 (denoted as nano 1 hereafter). In addition, its protective effect on the peri-implantitis diseases was determined. The peri-implantitis animal model was established and the compound was given for indicated treatment. The macrophages polarization in the periodontal tissue was detected with flow cytometry. Then, Enzyme Linked Immune Sorbent Assay (ELISA) detection kit was performed to measure the Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) content in the tissues after compound treatment.