Effect of hepatocyte growth factor (HGF) on human islet total cellular insulin content and insulin secretory capacity after exposure to pro-inflammatory cytokines.

Results are reported as % recovery of total cellular insulin relative to untreated controls (islets alone). Islet function is assessed by a static glucose stimulated insulin release assay. The stimulation index (SI) is calculated as a ratio of insulin release at high glucose versus low glucose. Insulin release (% insulin content) is reported as insulin secreted at 2.8 mM glucose or 20.0 mM glucose divided by insulin content for corresponding islets. Values are expressed as mean ± SEM.*p†p‡p